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Interactions of potyviral protein HCPro with host methionine cycle enzymes and scaffolding protein VARICOSE in potato virus A infection

Swarnalok De

Potyviral helper component proteinase (HCPro) is a quintessential example of a multifunctional viral protein. Its name comes from two of its earliest identified functions- ‘Helper Component’ involved in aphid-mediated plant-plant transmission of the virus, and cysteine proteinase responsible for its self-cleavage from the rest of the viral polyprotein. HCPro’s best-studied function is it...

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Väitöstilaisuus: 17.1.2019

Effects of musical experience on children?s language and brain development

Tanja Linnavalli

The present thesis investigated the maturation of children’s neural speech-sound discrimination, its links to behavioral linguistic measures and whether participating music playschool affects these skills. Neural speech-sound discrimination was studied by recording children’s (N=75) event-related potentials (ERP) to different speech-sound changes with electroencephalography (EEG), four t...

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Väitöstilaisuus: 17.1.2019

To make the short story long - The development of the frame-story structure in Sanskrit literature: The Vedic and Epic models

Virpi Hämeen-Anttila

The dissertation is interdisciplinary: it is divided between South Asian studies and comparative literature. Its special area is Sanskrit literature. It investigates first frame structures in Vedic literature (ca. 1200 - 500 BCE) and follows the development of the frame to the age of the epics Mahābhārata and Rāmāyaṇa (ca. 400 BCE - 300 CE). In the material, the “omphalos” and dialogue h...

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Väitöstilaisuus: 18.1.2019

Causal effects in macroeconomics through higher moments

Jaakko Nelimarkka

This dissertation contains three essays that examine causal effects in macroeconomics by identifying structural shocks and measuring their propagation through higher and time-varying moments of data. In particular, the use of non-normal distributions provides more conditions for identification when conventional methods cannot distinguish the underlying macroeconomic shocks. I complement ...

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Väitöstilaisuus: 18.1.2019

"Minä uskon hyvää elämään." : Nuoret ja elämänkulussa rakentuva toimijuus

Anna Juntunen

Tässä kirkkososiologian väitöstutkimuksessa tarkasteltiin 14-20-vuotiaiden nuorten elämänkulkuihin liittyvää toimijuutta. Tutkimus koostuu neljästä osajulkaisusta, joissa nuorten elämänkuluissa rakentuvaa toimijuutta tutkittiin ulkopuolisuuden kokemusten, koulutuksellisten ja ammatillisten valintojen, hyvän elämän näkemysten ja käännekohtien näkökulmista. Teoreettisena viitekehyksenä ova...

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Väitöstilaisuus: 18.1.2019

Thiol-ene based microfluidic devices for bioanalysis

Sari Tähkä

Microfluidic devices have been noticed potential platforms for bioanalytical research. The small size enables rapid analyses, reduced sample and reagent consumption and microtechnology allow integration of multiple analytical units on-chip. Despite the progress made in the past years, the current materials for these devices have challenges with the cost and/or mass production possibiliti...

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Väitöstilaisuus: 18.1.2019

Diagnostics and monitoring of chronic virus infections: evaluation of novel molecular methods and markers

Elina Virtanen

Chronic virus infection is a state where the virus persists in the body after primary infection. Primary infection can be asymptomatic and may remain unnoticed, but gradual replication of the virus, or a change in the immunological status of the host, may lead to the development of severe or even fatal disease. Symptoms and risk factors of virus-induced diseases have to be monitored to i...

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Väitöstilaisuus: 18.1.2019

Etsiä, hoivata, leikkiä. - Maagisen ajattelun rikastuminen; intuitiivinen ajattelu ja emootiot parantamiseen liittyvässä etnografisessa aineistossa

Outi Pohjanheimo

Miksi ihmiset hakevat apua vaihtoehtohoidoista sellaisiinkin sairauksiin, joita lääketiede voisi parantaa? Tutkimusta varten Pohjanheimo osallistui sekä karismaattis-kristillisiin parantamisiltoihin että reikihoitokursseille. Hän kiinnostui siitä, ilmaistaanko niissä kaikille ihmisille yhteisiä intuitiivisia oletuksia ja odotuksia parantamisesta ja parantumisesta, ja selittääkö se vaihto...

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Väitöstilaisuus: 18.1.2019

FINEMAP: a statistical method for identifying causal genetic variants

Christian Benner

The explosion of genomic data during the last ten years and the advent of Genome-Wide Association Studies (GWAS) have led to robust statistical associations between thousands of genomic regions and hundreds of phenotypes. However, any one associated genomic region can harbor thousands of correlated genetic variants, complicating the understanding of the underlying biological mechanisms t...

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Väitöstilaisuus: 18.1.2019

THE EFFECT OF LIVING ENVIRONMENT AND ENVIRONMENTAL EXPOSURE ON THE COMPOSITION OF MICROBIAL COMMUNITY IN SOIL, ON HUMAN SKIN AND IN THE GUT

Anirudra Parajuli

Microbes play important roles in the development of the human immune system. Human commensal microbiota of the gut and skin have been shown to modulate the immune system, and high diversity of this microbiota is likely to confer protection against immune-mediated diseases. However, sufficient contacts with the diverse microbiota in our environment have also been thought to be equally imp...

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Väitöstilaisuus: 18.1.2019

Synthesis of Abietane-Type Diterpenoids with Anticancer Activity

Laura Kolsi

Natural products and their derivatives are excellent starting points in drug design and widely studied as promiscuous anticancer agents. Moreover, they represent a big part of the current anticancer drugs in clinical use. Pancreatic cancer is one of the most fatal cancers with an extremely low five-year survival rate and increasing incidence. This cancer is particularly hard to target be...

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Väitöstilaisuus: 19.1.2019

The Forestland's Guests - Mythical Landscapes, Personhood, and Gender in the Finno-Karelian Bear Ceremonialism

Vesa Matteo Piludu

The goal of the thesis is to provide new approaches for the interpretation of the elaborate Finnish and Karelian bear ceremonial’s songs, which were intensively collected in the 19th Century and in the early 20th Century. The study aims to furnish a better understanding of the meanings of the ceremonial taking in consideration the context of folk beliefs at the time. The chapters will co...

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Väitöstilaisuus: 19.1.2019

GENETICS OF PRIMARY IMMUNODEFICIENCY IN FINLAND

Luca Trotta

Primary Immunodeficiency (PIDs) categorize a broad and heterogeneous group of inborn immunity errors. Despite being generally quite rare, PIDs collectively account for consistent morbidity and mortality. Currently, more than 350 monogenic PIDs have been recognised to embody clinical phenotypes ranging from life-threatening infections to autoimmune/inflammatory diseases, allergies and/or ...

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Väitöstilaisuus: 24.1.2019

Take not Jews and Christians as Intimates! : Depictions of Jews and Christians in Modern Shīʿi Qurʾānic Exegesis

Maria Pakkala

Modern Shīʿi commentaries on the Qurʾān are understudied in comparison with their classical or Sunni counterparts. This dissertation attempts to fill in some of this academic lacuna by shedding light on one of the major Shīʿi Qurʾānic commentators of our times. The topic of my research is the perception of Jews and Christians in the thought of the Lebanese Shīʿi scholar Grand Ayatollah a...

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Väitöstilaisuus: 25.1.2019

Developing official control in Finnish slaughterhouses

Jenni Luukkanen

Official control in slaughterhouses, consisting of meat inspection and food safety inspection, has an important role in ensuring meat safety, animal health and welfare, and prevention of transmissible animal diseases. Meat inspection in the European Union (EU) includes the inspection of food chain information, live animals (ante-mortem inspection), and carcasses and offal (post-mortem in...

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Väitöstilaisuus: 25.1.2019

Visualizing congestion with ultrasound - diagnostic and therapeutic implications

Jonas Öhman

The syndrome of Acute Heart Failure (AHF) is a very common cause for hospitalization, and carries a poor prognosis both in hospital and after discharge. The syndrome is caused by a various disease of the cardiovascular system and the heart. Congestion due to elevated cardiac filling pressures is the key physiological feature in AHF. There is to date very little evidence-based therapy exi...

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Väitöstilaisuus: 25.1.2019

Arterial Embolization in Gastrointestinal Bleeding

Taina Nykänen

Gastrointestinal bleeding is a common surgical emergency resulting in significant morbidity and mortality. The first line intervention in most cases is therapeutic endoscopy. When endoscopy fails or is not feasible, the traditional second line treatment is surgery. Emergency surgery is associated with significant morbidity and mortality, and the less invasive transcatheter arterial embol...

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Väitöstilaisuus: 25.1.2019

Kolme kriisiä ja kansalliset rahapelit : Yhteiskunnallisten murroskausien vaikutus suomalaisen rahapelijärjestelmän muotoutumiseen

Jukka Ahonen

The study analyzes the historical formation of the Finnish gambling system with particular focus on non-economic factors related to the legalization of gambling. The development of the gambling system is examined from the perspective of three periods which turn out to be critical turning points in society. Firstly, the start of football pools during the year of the Winter War, 1940, and ...

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Väitöstilaisuus: 25.1.2019

Obesity and associated health risks - outcomes of maternal early pregnancy obesity and child's cognition

Satu Kumpulainen

Alarming rates of the world’s adult population is meeting the criteria for obesity. Moreover, increasing amount of women at reproductive age are entering pregnancy with obesity. Growing evidence suggests that excessive maternal weight during pregnancy does not only pose a risk for poorer maternal physical and mental health but is also resulting in adverse outcomes in offspring. One of th...

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Väitöstilaisuus: 25.1.2019

Masentuneen elämänhallinnan tukeminen perusterveydenhuollossa

Anneli Kuusinen-Laukkala

Depression is a multi-faceted syndrome both in view of the background and support, treatment and rehabilitation and thus a big challenge in the whole society. To be able to prevent and treat it individually we need multiple ways to recognize determinants and risk factors of depression. The family, the nearests and the work are in the main role in developing and supporting the sense of co...

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Väitöstilaisuus: 25.1.2019

Chlamydia trachomatis and Reproductive health

Tiina Rantsi

Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection (STI) worldwide. It has been linked to severe reproductive morbidity, including tubal factor infertility (TFI), ectopic pregnancy (EP), miscarriage and preterm delivery (PTD), but the evidence has mostly been based on clinical case-control studies, and the data retrieved from population-based stud...

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Väitöstilaisuus: 25.1.2019

Underlying Mechanisms of Prolyl Oligopeptidase Inhibition, Deletion, and Restoration on the α-Synuclein Aggregation Process

Reinis Svarbachs

Neurodegenerative disorders are characterized by accumulation of toxic protein species that are followed by a gradual loss of neurons in certain brain regions and person’s loss of movement and dementia. The cause of the protein accumulation is not fully understood but is partially influenced by the disturbances in the protein degradation pathways, post-translational protein modifications...

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Väitöstilaisuus: 25.1.2019

Glucuronidation activity of individual UDP-glucuronosyltransferases : Comparison of activity and substrate specificity among recombinant human UGT enzymes and differences between dog and human subfamily 1A UGT enzymes

Johanna Troberg

UDP-glucuronosyltransferases (UGTs) are a group of important conjugation enzymes that transfer a sugar moiety from UDP-glucuronic acid onto a nucleophilic group in substrate compounds. This glucuronidation reaction converts compounds into more water-soluble forms, and thereby enhances their excretion into bile, feces or urine. Frequently prescribed drugs are often eliminated through gluc...

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Väitöstilaisuus: 25.1.2019

Studies on Neural Mechanisms Underlying Emotions : Experiments with pharmaceutical and physiological stimuli on behavior and brain signals in rodents and non-human primates

Zuyue Chen

This thesis investigated aspects of emotion processing by applying behavioral testing, pharmacological manipulations and electrophysiological recordings in animal experiments, and focused on questions that have relevance in understanding human emotion processing. Studies I and II aimed at elucidating whether paracetamol, a widely used pain-killer and fever-reducing medication, might also...

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Väitöstilaisuus: 25.1.2019

Associations between circadian factors and noncommunicable diseases; A population-based study in Finland

Syaron Basnet

The aim of this thesis was to study the association between circadian factors and common noncommunicable diseases. To our knowledge, these associations have not been investigated before in a large population-based cohort. The study of these associations is important as the global morbidity and mortality rates for noncommunicable diseases are increasing. Thus, there is a need to better un...

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Väitöstilaisuus: 25.1.2019

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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