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Developmental origins of mental health : Human observational studies of preterm birth, antenatal synthetic glucocorticoid exposure, and maternal depressive symptoms during pregnancy

Elina Wolford

Mental disorders are a considerable factor in the global burden of disease, with population growth and aging increasing the prevalence of the disorders. While interventions and treatment to ameliorate the burden of mental disorders is important, another critical goal is to find possible risk factors for optimal mental health. According to the Developmental Origins of Health and D...

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Public examination: 12.12.2018

ANCA-associated vasculitis: studies on clinical presentation and factors involving disease activity and outcome

Anna Salmela

Aims. The aim of this study was to investigate the factors associated with long-term prognosis and disease activity in patients with anti-neutrophil cytoplasm autoantibodies (ANCA)-associated vasculitis (AAV). An additional aim was to define the coagulation and fibrinolysis profile of renal AAV patients. Methods. Four cohorts including patients with granulomatosis with polyangiitis (GPA)...

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Public examination: 13.12.2018

Cracks in the mirror - The ideal worker and the labor process in Finnish working life after the Second World War

Pekka Varje

In this dissertation I examine the transformation of the ideal worker from a rational, rule-abiding subordinate of the Fordist organization to an emotional and individualized subject of the post-Fordist organization in Finland from the 1940s to the 2000s. The dissertation takes a comparative approach, setting the public representations of the ideal worker against worker experiences from ...

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Public examination: 13.12.2018

Location Data, Personal Data Protection and Privacy in Mobile Device Usage: An EU Law Perspective

Shakila Du-Pasha

Using location-based services (LBSs) via location-aware applications (apps) and websites on devices including smartphones, tablets and laptops has become inevitable for most device users. Smartphones and smart devices are equipped with sophisticated positioning sensors that can determine the location and physical movements of their users. A variety of risks and threats have been associat...

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Public examination: 14.12.2018

Patient safety in maternity hospitals in Finland

Elina Karalis

The number of delivery units in Finland has been decreasing and care has been centralized to larger units. The main reasons for this are: the decreasing number of babies born annually, the legislation for 24/7 readiness for emergency Caesarean section and the legislation to close units with less than 1000 annual deliveries. To improve the obstetric care in Finland, this study investigate...

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Public examination: 14.12.2018

Flying jewels - Taxonomy and distribution of Northern European cuckoo wasps (Hymenoptera: Chrysididae)

Juho Paukkunen

Cuckoo wasps (Chrysididae) include more than 2500 described species, all of which are parasitoids or kleptoparasites of other insects, predominantly solitary wasps and bees. They favor warm, dry and sunny habitats, and their bodies are typically highly sculptured with bright metallic colours. About 490 species are currently known in Europe, but the actual number of species is estimated a...

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Public examination: 14.12.2018

Management of pikeperch (Sander lucioperca) in the coastal waters of the Baltic Sea

Kari Saulamo

Fisheries management needs to address an array issues to achieve long-term sustainability. Economically viable fisheries require healthy fish stocks. Our knowledge of fish populations is still limited, as fish cannot be observed directly and they are typically highly mobile. Fish populations also fluctuate temporally and spatially depending on the biophysical characteristics of the envir...

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Public examination: 14.12.2018

Metabolomic Characterization of Canine Behavioural Disorders: Fearfulness and Hyperactivity/Impulsivity

Jenni Puurunen

Psychiatric disorders in humans and their counterparts, behavioural disorders in dogs, are the major welfare problems in both species affecting the wellbeing of millions of people and dogs worldwide. Despite extensive research elucidating the pathobiological events leading to the onset of psychiatric/behavioural disorders, the exact etiology remains unattainable. Moreover, the complexity...

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Public examination: 14.12.2018

Quality of surgical treatment in breast cancer

Kaisu Ojala

The purpose of this study was to evaluate the quality of surgical treatment in breast cancer in various aspects: treatment processes, surgical procedures, waiting times, day surgery and aesthetic and functional outcomes. In addition, a special emphasis was put on the surgical treatment of elderly breast cancer patients. In study I, the study population consisted of 1307 patients undergoi...

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Public examination: 14.12.2018

Correlated Intellectual Property Rights: A Foundational Solution to the Problems of Patent Holdup and Patent Holdout

Ricky James

This thesis advocates replacing the exclusive rights doctrine with the correlated rights doctrine in circumstances, where an integrated technological product requires the practice of several patents from multiple owners. The justification for application of the correlated rights doctrine is based upon the principles of equity and non-discrimination, which demand that every IP owner contr...

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Public examination: 14.12.2018

Innovation Capacity and Women Empowerment - Identifying constraints and pathways toward sustainability, improved productivity and livelihoods of small-scale farmers in Africa

Mila Sell

This thesis approaches some of the global challenges of the coming decades, including climate change, biodiversity loss, growing populations, and food insecurity, from a small-scale farmer’s perspective. In Africa small-scale farmers still account for up to 70% of the population, and represent the poorest and most vulnerable group to these challenges. They are, however, a heterogeneous g...

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Public examination: 14.12.2018

Hirschsprung's disease - Long-term outcomes and pathophysiology of bowel dysfunction

Malla Salli

Background. Patients with Hirschsprung’s disease (HD) have significant post-operative morbidity due to Hirschsprung-associated enterocolitis (HAEC) and other bowel function disturbances, but their exact etiology is still unknown. Transanal endorectal pull-through (TEPT) has suggested to cause some of these problems, but controlled long-term studies are lacking. The relation of bowel dysf...

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Public examination: 14.12.2018

Unfolding lipid profile- and sex-paradoxes in the epidemiology of subarachnoid haemorrhage

Joni Lindbohm

Introduction In cardiovascular diseases, high total cholesterol (TC) and male sex usually associate with elevated risk. However, studies of aneurysmal subarachnoid haemorrhages (aSAHs), report paradoxically that low TC and female sex elevate aSAH risk. Additionally, no population-based studies on the risk factors behind the most-fatal aSAH: sudden-death aSAHs, exist. This thesis aims to ...

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Public examination: 14.12.2018

Alterations in Myocardial Function and Electrocardiology in Hypertrophic Cardiomyopathy

Mikko Jalanko

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy with a highly variable phenotype. The assessment of arrhythmogenic potential in HCM patients and identification of early signs of the disease in relatives of HCM patients is challenging. The aim of this thesis was to characterize the mechanical and electrical changes in the left ventricle of carriers of either ...

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Public examination: 14.12.2018

Immunomodulatory Effects of Engineered Nanomaterials in Healthy and Diseased Lungs and Skin

Marit Ilves

Nanotechnology is exerting a huge impact on various sectors of everyday life as it has a tremendous potential for revolutionizing a long list of consumer products and industrial applications. The key to success in the nanotechnology field lies in the fact that materials at the nanoscale possess novel and enhanced properties such as greater strength and improved conductivity when compared...

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Public examination: 14.12.2018

Strategies for Medication Safety: - An Organization-Based Approach Focusing on High-Alert Medications and Clinical Pharmacy Services in Helsinki University Hospital

Lotta Schepel

Medication errors are one the most important preventable factors jeopardizing patient safety. According to the ongoing World Health Organization’s third Global Patient Safety Challenge on medication safety, the key risk areas are high-risk situations, polypharmacy, and transitions of care. Extending pharmacists’ involvement in patient care and patient-safety work has been systematically ...

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Public examination: 14.12.2018

Tutkijakoulutus, tieto ja tutkijuus tietokapitalistisessa hallinnassa

Kristiina Hannukainen

Tarkastelen korkeakoulupoliittiseen keskusteluun paikantuvassa tutkimuksessani tutkijakoulutuksen tietokapitalistista hallintaa. Tietokapitalistisella hallinnalla tarkoitetaan tiedon ja tieteen sekä tiedon tuottajien toiminnan ja tietämisen yhä tehokkaampaa taloudellista hallintaa. Tutkimuksessani syvennyn tietokapitalistisen hallinnan seurauksiin tutkijoiden ja tutkijakoulutettavien toi...

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Public examination: 14.12.2018

Selection for welfare and feed efficiency in Finnish blue fox

Riitta Kempe

The aim in blue fox selection is to improve reproduction traits, fur quality and size. Animal health, welfare, conformation traits or feed efficiency also show genetic variation and can be selected along with these traits. Due to unfavourable changes in blue fox conformation and health traits, there is a need to investigate how the focus in current selection should be changed to improve ...

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Public examination: 14.12.2018

Treatment seeking, treatment adequacy and outcome of depressive and anxiety disorders among young adults in Finland - Findings from a population-based sample

Teija Kasteenpohja

According to epidemiological studies, depressive and anxiety disorders are common, often chronic or recurrent, but under-recognized and undertreated. The incidence of these disorders peaks in late adolescence and early adulthood, when they may be particularly harmful, since they often limit social, occupational and academic functioning. Therefore, recognition and adequate treatment of th...

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Public examination: 14.12.2018

Pispalan ars poetica - Lauri Viidan runojen metalyyrisyydestä

Erika Laamanen

TVäitöskirja käsittelee Lauri Viidan (1916−1965) poetiikkaa sellaisena kuin se ilmenee hänen runoteoksissaan Betonimylläri (1947), Kukunor. Satu ihmislapsille (1949), Käppyräinen (1954) ja Suutarikin, suuri viisas (1961). Runoja, jotka tarkastelevat omaa poeettista olemustaan, kutsutaan metalyriikaksi. Hyödyntämällä Eva Müller-Zettelmannin metalyriikan teoriaa ja Shlomith Rimmon-Kenanin ...

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Public examination: 14.12.2018

Bayesian latent factor approaches for modeling ecological species communities

Gleb Tikhonov

In the last decades, the aims of research in community ecology have been shifting from the mere description of observed patterns towards a mechanistic perspective that seeks to understand the processes shaping observed species communities. Simultaneously, the technical advances in data collection techniques dramatically raised the amount and quality of ecological data annually obtained a...

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Public examination: 14.12.2018

Discovery of cardioprotective isoxazole-amide compounds targeting the synergy of transcription factors GATA4 and NKX2-5

Mika Välimäki

Acute myocardial infarction is a life-threatening condition that occurs as a result of reduced blood flow in the cardiac muscle, eventually leading to tissue damage. In infarcted areas, cardiomyocytes have insufficient ability to proliferate and replace the injured cells, which is associated with a deficient pumping capacity. A strictly regulated combinatorial interplay of transcription ...

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Public examination: 14.12.2018

PERSONAL DATA PROTECTION ON THE INTERNET OF THINGS AN EU PERSPECTIVE

Jenny-Sofia Lindqvist

As the traditional Internet has developed into the The Internet of Things (‘IoT’), personal data protection law has also expanded from being a niche field of law, into a legal area that is applicable in almost all sectors, services, and technologies. Globalisation and the vast technological development, and elaborated collection of data, has raised questions about whether the current EU ...

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Public examination: 15.12.2018

Animism and Interconnectivity - Batek and Manya? Life on the Periphery of the Malaysian Rainforest

Ivan Tacey

Animism and Interconnectivity is an ethnographic study of Batek Dè’ and Manya’ religion on the periphery of the Malaysian rainforest. In the twenty-first century, the lives of these two small-scale groups of former hunter-gatherers take place on the interconnected frontier between forest and the outside world, a nexus of different ideas, peoples and objects of diverse origins. Through an...

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Public examination: 15.12.2018

Valtio ja suurteollisuuden synty - Laivanrakennusteollisuuden kehittyminen yhteiskunnallisissa teknopoliittisissa järjestelmissä Suomessa 1918-1954

Aaro Sahari

Tässä tutkimuksessa sotakorvausten, valtion teollisuuspolitiikan, idänkaupan ja laivanrakennusteollisuuden historiat asetetaan yhdeksi kokonaisuudeksi. Makrotalouden yleisten kasvukertomusten ja idänkaupan veijaritarinoiden katveet tulevat yksityiskohtaisesti käsitellyiksi. Teknologia ja sen rakentajat nousevat esiin politiikan ja talouden tuttujen kertomusten takaa täydentäen kertomusta...

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Public examination: 15.12.2018

Tilltal i reklamfilm - Du-reformen i ett historiskt perspektiv

Maria Fremer

I den här studien analyserar jag du-reformen från ett sociolingvistiskt perspektiv, genom en undersökning av tilltalsformer i bruk. Materialet består av sverigesvenska reklamfilmer. En del är korta annonsfilmer som visats före huvudfilmen på bio, andra är längre filmer (framför allt så kallade husmorsfilmer) som visats på separata föreställningar. Den äldsta filmen är från 1915 och den n...

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Public examination: 15.12.2018

Polkuja suomalaiseen tasa-arvoon? - Kansalaistoiminta, Tahdon2013 ja translaki

Nina Järviö

Kansalaisaloitteesta tasa-arvoisen avioliittolain puolesta tuli kautta aikain ensimmäinen suomalainen kansalaisaloite, jonka esittämä lakiuudistus on hyväksytty eduskunnan käsittelyssä. Aloitetta ajoi poikkeuksellisen näkyvästi Tahdon2013-kampanja, ja lähes kaikilla vaikutti olevan mielipide siitä, tulisiko samaa sukupuolta olevien parien avioliitot mahdollistaa vai ei. 2010-luvulle tult...

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Public examination: 15.12.2018

Analysis of molecular mechanisms in intestinal stem cells and colorectal cancer progression

Jenny Högström-Stakem

Colorectal cancer (CRC) is one of the leading causes of cancer related mortality in Western countries. Activation of the Wnt signaling pathway is the initiating event in the majority of human CRCs. Further mutations in tumor suppressors and oncogenes, such as KRAS and the TGF signaling pathways, are required for carcinoma development. In the intestine, the orphan G-protein coupled recep...

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Public examination: 17.12.2018

Bayesian analysis of nonlinear and non-Gaussian time series models

Ming Yin

This thesis is a collection of three self-contained essays on using sequential Bayesian methods together with efficient parallel computing strategies, to estimate nonlinear and non-Gaussian econometric/financial time series models. In the past few decades, Bayesian inference has played an increasingly important role in time series econometrics, which, in my opinion, is the consequence of...

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Public examination: 19.12.2018

Phosphorylation of the α- and β-chains of LFA-1 regulates its interaction with cytoplasmic proteins and crosstalk to VLA-4 integrin

Farhana Jahan

Inflammation is a defense response of the body to an event of injury or tissue damage. Leukocytes circulating in the bloodstream are stimulated by chemokines released by endothelial cells that enable them to adhere and transmigrate to the site of infection. Leukocyte extravasation from the blood vessels towards the site of inflammation is a sequential and overlapping process involving le...

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Public examination: 20.12.2018

Genetic predisposition to colorectal cancer in young patients and in the general population

Tomas Tanskanen

Colorectal cancer (CRC) is the third most common cancer worldwide and accounts for 10% of all new cancers. The purpose of this thesis was to provide new insights into the genetic architecture of CRC susceptibility, as well as the identification of individuals with substantial genetic risk. The first aim was to study the diagnostic approach to hereditary cancer syndromes in early-onset CR...

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Public examination: 20.12.2018

Biomarkers in pheochromocytomas and paragangliomas

Helena Leijon

Pheochromocytomas (PHEOs) derived from adrenal medulla and paragangliomas (PGLs) from sympathetic or parasympathetic paraganglia are rare neuroendocrine tumors. Incidence of PHEOs and PGLs is between 0.4–9.5 cases per one million people per year. In Finland about 10–15 PHEOs are diagnosed per year, but the incidence is rising. PHEOs and sympathetic PGLs can secrete catecholamines, often ...

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Public examination: 21.12.2018

Modification of bare and functionalized Au(111) surfaces and ferromagnetism of Au and Pd nanoclusters

Annika Venäläinen

The purpose of this thesis is to provide a better understanding of the properties of surfaces covered by self-assembled monolayers (SAMs) as well as the magnetic properties of interacting nanoclusters of gold and palladium. Surfaces covered by SAMs were studied by investigating their possible metallization as well as the morphological changes in bare and SAM covered Au(111) surfaces indu...

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Public examination: 21.12.2018

Classification and clustering in media monitoring: from knowledge engineering to deep learning

Lidia Pivovarova

This thesis addresses information extraction from financial news for decision support in the business domain. News is an important source of information for business decision makers, which reflects investors’ expectations and affects companies’ reputations. A vast amount of various news sources forces development of text mining algorithms to collect most crucial information and present t...

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Public examination: 21.12.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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