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Seven shades of tamoxifen resistance - Molecular mechanisms of drug resistance in breast cancer

Susanne Hultsch

Tamoxifen treatment of estrogen receptor-positive breast cancer reduces breast cancer mortality. However, resistance to tamoxifen develops frequently. A plethora of resistance mechanisms have been described but their biological importance, clinical significance, and possibilities for diagnostic or therapeutic intervention are poorly understood. Fusion genes, for example, have the potenti...

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Public examination: 23.10.2018

Taxon free analysis of mammalian communities in relation to evolutionary survivorship and environmental factors

Kari Lintulaakso

This thesis study examines how different species traits are related to the evolutionary survivorship of land mammal taxa and how the trait structure of mammalian communities is related to the climate, habitats and biogeography at the continental level. The study uses large datasets of both fossil and present land mammals from different continents. The results of the evolutionary survivor...

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Public examination: 24.10.2018

Fungal Communities in Boreal Forest Soils: The Effect of Disturbances, Seasons and Soil Horizons

Minna Santalahti

Boreal forest soils store a significant amount of carbon and function as a terrestrial net sink in the global carbon cycle. Soil microbes perform essential ecological functions by cycling nutrients and decomposing organic matter. Fungi are the predominant decomposers and central to the turnover of carbon and nitrogen in boreal forest soils. The production of various extracellular enzymes...

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Public examination: 26.10.2018

TAU PATHOLOGY: SECRETION AND INTERNALIZATION AS THE KEY FOR UNDERSTANDING PROTEIN PROPAGATION

Cecilia Anna Brunello

Abnormal regulation of the microtubule-associated protein Tau leads to its misfolding, aggregation, and impairment of its physiological functions. Deposits of insoluble Tau are the hallmark of several neurodegenerative disorders called tauopathies. Tauopathies are characterized by the transcellular transfer of phosphorylated oligomeric Tau, which propagates the pathology along connected ...

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Public examination: 26.10.2018

Pharmacokinetic Interactions and Pharmacogenetics of Clopidogrel, Prasugrel and Ticagrelor

Mikko Holmberg

The antiplatelet drugs clopidogrel, prasugrel and ticagrelor are used to treat and prevent atherothrombotic events. They inhibit platelet activation by blocking the platelet P2Y12 adenosine diphosphate (ADP) receptor. Considerable variation exists in the pharmacodynamics and therapeutic response to clopidogrel treatment due to pharmacogenetic factors and drug-drug interactions. The newer...

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Public examination: 26.10.2018

Surgical treatment of Crohn's disease

Gisele Aaltonen

Background: Crohn’s disease (CD) is a chronic inflammatory bowel disease that can affect any part of the gastrointestinal tract. It most commonly affects the terminal ileum and causes transmural inflammation of the bowel wall resulting in stenosis, fistula or abscess formation. Medication is the treatment of choice for CD, although most patients will require surgery at some point as a re...

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Public examination: 26.10.2018

Prenatally Detected Hydronephrosis - The Incidence and Diagnostics of Vesicoureteral Reflux and Urinary Tract Infections

Sofia Visuri

Hydronephrosis is one of the most common prenatally detected abnormalities. Our target was to study the incidence of VUR and urinary tract infection (UTI) in children with prenatally detected hydronephrosis. We investigated the incidence VUR and UTI in children with simple hydronephrosis, hydroureter, duplex collecting system or ureterocele

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Public examination: 26.10.2018

Cardiovascular Magnetic Resonance Evaluation and Risk Stratification of Myocardial Diseases

Pauli Pöyhönen

Advanced cardiovascular magnetic resonance (CMR) may provide information of the myocardium beyond conventional imaging. The present thesis was designed to assess whether myocardial tissue characterization by CMR improves the diagnostic and prognostic evaluation of non-ischemic cardiomyopathies (NICMs) (studies I-III) and ischemic heart disease (IV).

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Public examination: 26.10.2018

Mediation and the legal system - Extracting the legal principles of Civil and Commercial Mediation

Petra Hietanen-Kunwald

It is common to perceive mediation as a social practice, a practice that takes place outside the law and is unrestricted by legal rules. The subject of my dissertation is the normative dimension of mediation. I seek to sketch the relationship between mediation and the legal system, to discern, interpret and systematize the legal rules and principles within the framework of the European M...

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Public examination: 26.10.2018

Computational analysis of orexin receptors and their interactions with natural and synthetic ligands

Lasse Karhu

The orexinergic system is a key regulator of the sleep-wake cycle, and as such, presents a prominent target for drug development against ailments such as insomnia and narcolepsy. The system comprises two G protein-coupled receptors (GPCR), OX₁ and OX₂, and two neuropeptides, orexin-A and orexin-B. In the beginning of the study presented here, several antagonists (blockers) of the recepto...

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Public examination: 26.10.2018

Theory of Control Tuning: The Processing of Control in Migration-related Place Coping

Saija Niemi

In this study, I present a new theory – the Theory of Control Tuning – which demonstrates the importance of control in relation to migration. Control is a significant part of the every-day life of individuals and groups of migration actors, such as internally displaced persons, asylum seekers, recognised refugees, education- and employment-induced migrants, local residents and various au...

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Public examination: 26.10.2018

Exopolysaccharides produced by lactic acid bacteria in fava bean matrix

Yan Xu

Fava bean is a good source of plant protein that is increasingly gaining attention due to its health benefits and sustainability. However, the addition of fava bean flour or protein concentrate at high concentrations to food products may result in an unsatisfying texture. Therefore, texture modification of the fava bean matrix is essential to improve its usability in various food systems...

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Public examination: 26.10.2018

INTERPRETATION OF SHARE AND BUSINESS ACQUISITION CONTRACTS - A Study of Anglo-American Concepts and Practices Influencing Share and Business Aquisitions, of Compatibility with Nordic Law and of Possible Effects on Interpretation of Contracts Governed by Nordic Law

Nina Wilkman

This dissertation discusses contract interpretation based on a certain kind of contracting and contracts. It is submitted that sales and purchases of businesses (‘transactions’), regardless of whether transactions involve shares, assets or combinations of these, set a different framework for contract interpretation than many other contractual relationships. The transaction market is heav...

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Public examination: 27.10.2018

Puhumalla teoretisoitu? - Aineenopettajakoulutuksen kasvatustieteellistyminen ja asiantuntijapuhe 1970-luvulta 2010-luvulle

Mikko Puustinen

Tarkastelen aineenopettajien koulutuksen kehitystä ja opettajankoulutusta käsittelevän asiantuntijapuheen retoriikkaa 1970-luvulta 2010-luvulle. Tutkimuksen aineisto koostuu yliopistojen tutkintovaatimuksista, asiantuntijoiden tuottamista komitea- ja selvitysteksteistä sekä opiskelijoilta kerätystä kyselyaineistosta. Komitea- ja selvitystekstien analyysi perustuu retoriseen analyysiin, j...

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Public examination: 27.10.2018

INTRAOPERATIVE ASEPTIC PRACTICES AND SURGICAL SITE INFECTIONS IN BREAST SURGERY

Teija-Kaisa Aholaakko

Background and aims. Operating theatre (OT) personnel implement intraoperative aseptic practices (AP) to control and prevent surgical site infection (SSI). AP is considered important in both infection control (IC) and prevention (IP), despite the challenges of investigating the causality between APs and SSIs. This study introduces a project regarding co-creating intraoperative APs in the...

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Public examination: 27.10.2018

Teachers changing higher education - From coping with change to embracing change

irma Kunnari

This dissertation explored higher education teachers’ experiences in developing their professional practices and how change can be achieved successfully. The pedagogical development process in one university of applied sciences was the context of three sub-studies, which investigated teachers’ experiences utilizing strength-focused theoretical constructs, following the positive approach....

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Public examination: 27.10.2018

The role of plant-fungal interaction for the soil organic matter degradation in boreal forest ecosystem

Outi-Maaria Sietiö

The boreal forests are significant sinks for carbon, and the majority of the carbon present in boreal forests is stored in the soils. Especially in the organic layers of the boreal forest soils, a significant amount of the carbon is stored as complex polymers, which are rather stable and have a long residence time. In addition, these soils are considered to be nutrient poor since importa...

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Public examination: 2.11.2018

Equine general anaesthesia and its relatively high mortality rate - An investigation of some pharmacological options to reduce the cardiovascular side effects of routinely used sedative and anaesthetic agents

Annemarie de Vries

This thesis includes studies investigating several options to minimize the undesirable cardiovascular side effects commonly seen with some of the routinely used sedative and anaesthetic agents in horses, under both clinical and research conditions. In the first study, the effect of dobutamine on arterial blood pressure and cardiac output was investigated in horses anaesthetised with isof...

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Public examination: 2.11.2018

YHTEISKUNNAN JÄSENYYDEN EHDOT - ARJEN KANSALAISUUDEN RAKENTAMINEN JA PERUSPALVELUKOKEMUKSET VENÄLÄISTAUSTAISTEN PERHEIDEN KERTOMUKSISSA

Eveliina Heino

Maahan muuttaneiden arkea ja yhteiskunnan jäsenyyttä on Suomessa usein tarkasteltu kotoutumisen tai kulttuurisen erilaisuuden käsitteiden kautta. Tällöin huomio kiinnittyy ensisijaisesti siihen, mitkä tekijät auttavat tai estävät maahan muuttaneita täyttämään ennalta määritellyt kotoutumisen kriteerit tai miten oletetusta kulttuurisesta erilaisuudesta johtuvat erityiskysymykset voidaan r...

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Public examination: 2.11.2018

Genetic modifiers of CHEK2-associated and familial breast cancer

Taru Muranen

In Western countries lifetime risk of breast cancer is about 10%; one in every ten women will develop the disease. Susceptibility mutations and positive family history increase the risk. For example, a woman with a mutation in one of the high-risk genes, BRCA1 or BRCA2, has about 70% lifetime risk, but for a BRCA1/2-carrier woman with an affected first-degree relative the risk is even hi...

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Public examination: 2.11.2018

Paclitaxel-eluting Devices in Peripheral Vascular Interventions

Patrick Björkman

Background: Paclitaxel is a cytostatic agent that is widely used in oncologic treatment. It has also showed promising results in combating vascular restenosis. It is delivered via drug-coated balloons (DCB) or drug-eluting stents (DES). Peripheral artery occlusive disease (PAD) affects approximately 200.000.000 people worldwide. Therapeutic options for occluded or stenosed arteries inclu...

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Public examination: 2.11.2018

DEVELOPING EXPERIMENTAL METHODS TO UNDERSTAND ATMOSPHERIC NUCLEATION

Joonas Vanhanen

The effects of human civilization on Earth’s climate are undeniable. Some are due to emissions of greenhouse gases, some are due to atmospheric aerosol particles. In this thesis, the focus is on the aerosols. The complexity of the effects of the aerosol particles on the climate strive from high dynamics of the aerosol populations. A fraction of the aerosol particles are formed in the atm...

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Public examination: 2.11.2018

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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