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Concepts and Concept Learning in Physics - The systemic view

Tommi Kokkonen

Research in science education has long been concerned with a problem that students acquire conceptions which are unsatisfactory from the scientific point of view. These conceptions are also often robust and slow to change. The learning process whereby the students’ conceptions undergo a change is often viewed from the point of view of conceptual change. In this thesis, this traditional p...

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Disputationen: 22.11.2017

Haemodynamic Effects of MK-467 in combination with Medetomidine and Selected Sedative and Anaesthetic Agents in Dogs

Kati Salla

Medetomidine (MED), an 2-adrenergic agonist, is widely used in veterinary practice as a sedative and premedication agent, as it provides reliable sedation. However, the marked haemodynamic changes limit its use to only healthy patients. MK-467, a peripheral 2 -adrenoceptor antagonist, has been demonstrated to attenuate the early haemodynamic disturbances induced by MED with intravenous c...

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Disputationen: 24.11.2017

Obesity, sirtuins, cardiorespiratory fitness, and metabolic health - modeling acquired environmental effects

Sakari Jukarainen

Subcutaneous adipose tissue (SAT) dysfunction has been theorized to drive some of the effects of obesity on metabolic health. Sirtuin (SIRT) proteins and their activity have recently been proposed as possible mediators of subcutaneous adipose tissue dysfunction in obesity. SIRTs are NAD+-dependent deacylases that regulate various cellular functions (e.g. transcription factors) according ...

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Disputationen: 24.11.2017

Interthinking in Estonian Home Economics Education

Jaana Taar

Home economics education in Estonia has gone through remarkable developments within recent decades. Its content has widened and the learning approach in the curriculum has changed. Thus, meeting the requirements set by the curriculum can be challenging for the teachers. To support teachers in implementing the curriculum, there is a need to understand how students act in solving various t...

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Disputationen: 24.11.2017

Bisphosphonate treatment in children with osteogenesis imperfecta : Benefits and concerns

Ilkka Vuorimies

Osteogenesis imperfecta is an inherited disorder of connective tissue characterized by bone fragility and low bone mass. It is caused by quantitatively or structurally abnormal type I collagen. Bisphosphonates, a group of anti-resorptive drugs, are commonly used as a medical therapy in children with osteogenesis imperfecta. A large number of studies have demonstrated their beneficial eff...

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Disputationen: 24.11.2017

European bat lyssavirus type 2 in Finland - Surveillance, evolutionary analysis, and prevention with vaccination

Tiina Nokireki

European bat lyssavirus type 2 (EBLV-2) was first isolated in Finland from a Daubenton’s bat (Myotis daubentonii) in 2009. Rabies in bats was already suspected in 1985, when a Swiss biologist died in Finland of lyssavirus infection, later identified as EBLV-2 infection. However, the origin of the infection could not be confirmed at that time. In 2010–2011, during active surveillance stud...

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Disputationen: 24.11.2017

Neuropsychiatric symptoms in dementia and delirium

Eeva Hölttä

Dementia with neuropsychiatric symptoms (NPSs) and delirium are the two most important and challenging neurocognitive disorders among frail, older, multimorbid patients. Both disorders manifest with cognitive decline and multiple NPSs. Dementia patients are prone to delirium, and a large proportion of patients with delirium develops dementia in a few years. However, little is known about...

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Disputationen: 24.11.2017

Bioluminescence of Toxic Dinoflagellates in the Baltic Sea - From Genes to Models

Anniina Le Tortorec

Phytoplankton constitute the basis of food webs and are responsible for almost all photosynthesis in the open sea. Occasionally, given suitable conditions, one phytoplankton species can increase in abundance and form a mass occurrence known as a bloom. Harmful Algal Blooms (HABs), in turn, can have adverse effects on the ecosystem, for example causing oxygen depletion, clogging of fish g...

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Disputationen: 24.11.2017

Solid-phase microextraction based sampling techniques for the analysis of volatile organic compounds in the atmosphere

Luís Miguel Feijó Barreira

Volatile organic compounds (VOCs) comprise a large diversity of species that are emitted into the atmosphere from both biogenic and anthropogenic sources. These species play a key role in atmospheric photochemistry, due to their high reactivity with atmospheric oxidants, and in the formation and growth of secondary organic aerosols. The trace levels usually found in ambient air and the e...

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Disputationen: 24.11.2017

Actors' roles and perceptions on the opportunities to increase nature conservation effectiveness: A study of interaction between knowledge and policy process

Anna Salomaa

Scientific knowledge shows compelling evidence of intensifying global environmental problems such as biodiversity loss and climate change. Unfortunately, this knowledge has not been directly translated into actions that would have reversed these worrying trends. The effectiveness of conservation, i.e. its ability to produce a desired result, is the outcome of interaction between knowledg...

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Disputationen: 24.11.2017

The conundrum of pre-eclampsia - from candidate genes to complement system

A. Inkeri Lokki

The human pregnancy is a unique immunological process. The foetus is tolerated and nourished through the complex yet transient organ, placenta, which bears the genetic fingerprint of the developing baby. Human placentation involves several waves of invasion, whereby the placenta is deeply attached to layers of the uterine wall, through the mucosal lining of the uterus, the decidua and in...

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Disputationen: 24.11.2017

Татарская диаспора Финляндии: вопросы интеграции и сохранения идентичности

Ramil Belyaev

This research aims to study the integration experience and preservation of the ethnical identity of the Tatar ethnic diaspora in Finland. The relatively small diaspora of the Tatars from Nizhny Novgorod Province which appeared at the turn of the XIX–XX centuries, during its existence and activity has gone from consolidation and protection of religious and cultural traditions, preservatio...

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Disputationen: 27.11.2017

FUR ANIMAL EPIDEMIC NECROTIC PYODERMA PATHOLOGY, ETIOLOGY, AND EPIDEMIOLOGY

Heli Nordgren

In 2007 Finnish fur farmers detected new kind of signs in farmed mink, foxes and raccoon dogs (Finnraccoon). Mink had severe pyoderma in the head around eyes, mouth or ears or in the feet around the nailbeds. Finnraccoons developed painful abscesses in the paws between the toes. Foxes had severe keratoconjunctivitis that occasionally spread to the eyelids and to facial dermatitis. The ...

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Disputationen: 29.11.2017

Natural language processing system for business intelligence

Mian Du

The ongoing information explosion has a particular impact on business areas, involving corporate strategy and business decision-making. Business intelligence tools aim to help users to understand market trends, which is critical for their day-to-day operations. For example, it is a typical business intelligence task to effectively obtain accurate and relevant information about the compet...

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Disputationen: 29.11.2017

DOBERMAN HEPATITIS - Role of Immunological and Genetic Mechanisms

Hanna Dyggve

Doberman hepatitis (DH) is a rare and chronic inflammatory condition of the liver. The early diagnosis of DH is difficult, and Dobermans may be affected for months or years before the diagnosis. There is no curative treatment and the prognosis is poor if the condition is associated with clinical signs of liver failure. Unraveling the disease etiologyand pathogenesis would enhance the dia...

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Disputationen: 1.12.2017

From electronic structures to molecular-level cluster formation mechanisms in the atmosphere

Nanna Myllys

Atmospheric aerosol particles affect the global climate and human health. A large fraction of atmospheric clusters is formed as a result of collisions and favourable interactions between molecules. However, the exact mechanisms and participating compounds are not fully resolved. The cluster formation mechanisms at the molecular-level are essential to understand what kind of effects aeros...

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Disputationen: 1.12.2017

Multiscale studies of the peatland-atmosphere interactions in northern Eurasia

Pavel Alekseychik

North Eurasia (NE) is recognized as a region of high importance for the global climate change. Large and systematic shifts in temperature and precipitation, predicted for NE, are expected to cause irreversible disturbances in the ecosystem-atmosphere interactions. The region is dominated by natural boreal and arctic ecosystems, which are experiencing increasing levels of anthropogenic in...

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Disputationen: 1.12.2017

Learning for the Legal Profession - Swedish Jurists' Study Journeys ca. 1630-1800

Marianne Vasara-Aaltonen

This research examines the studies of Swedish jurists abroad from ca. 1630 to 1800. The focus is on students of the Academy of Turku with the help of its online database of matriculation records, which also contains biographical information on the students. Thus it has been possible to search among the students for those future jurists who had also studied at foreign universities. The re...

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Disputationen: 1.12.2017

The biodiversity hypothesis of allergy: The interrelations between the skin microbiota, allergic diseases and exposure to microbes in residential environments

Jenni Lehtimäki

Biodiversity on earth is threatened and already drastically decreased due to anthropogenic actions. The ravenous utilization of natural resources has reached the point of payback in the forms of climate change, diseased crops, and disturbed water cycles. Obviously, these changes influence wellbeing of mankind. Besides these measurable problems, an invisible world, which covers all...

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Disputationen: 1.12.2017

Adenoid cystic Carcinoma of salivary glands - diagnostic and prognostic factors and treatment outcome

Karoliina Hirvonen

In 35 years follow up it was noted that of those patients suffering from adenoid cystic carsinoma (ACC) of salivary glands, 54% of major salivary glands and 42% of minor salivary glands carcinoma patients were alive 10 years after treatment. One factor that significantly worsened the survival was distant metastases appearing during the follow up. They appeared in 50% of major- and 34% of...

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Disputationen: 1.12.2017

Systemic Exposure to Oral Infections - a Cardiometabolic Risk

John Liljestrand

Cardiometabolic risk indicates a cluster of factors predisposing to cardiovascular diseases (CVDs) and diabetes mellitus. Chronic infections may contribute to the total cardiometabolic risk e.g. via an increased systemic inflammation. Periodontitis and apical periodontitis (AP) are often asymptomatic and among the world’s most prevalent infectious diseases. If left untreated, the affecte...

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Disputationen: 1.12.2017

Reconstructing Merchant Multilingualism - Lexical Studies of Early English East India Company Correspondence

Samuli Kaislaniemi

This dissertation investigates the multilingual practices of 17th-century English East India Company merchants, as revealed by the vocabulary they used in the texts they produced while stationed in the East Indies. The English East India Company (EIC) was founded in 1600. At first it was a moderately successful trading company, but in the 18th and 19th centuries the EIC rose to dominate ...

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Disputationen: 2.12.2017

Voxel-level dosimetry of 177Lu-octreotate: from phantoms to patients

Eero Hippeläinen

In radionuclide therapy, the patient is injected with relatively high amounts of therapeutic radiopharmaceutical which localises to target tissue and emits ionising radiation. Unfortunately, a perfectly targeting radiopharmaceutical has not been discovered and part of the radiopharmaceutical accumulates to healthy tissues, which are also thus irradiated. In order to ensure safe use, the ...

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Disputationen: 2.12.2017

Utility and Impact of Detecting Clinically Important Bacteria with Small-Scale and Automated Nucleic-Acid Amplification Assays

Jari Hirvonen

During the last decade, nucleic acid-based amplification techniques (NAATs) have revolutionized the way clinical microbiology laboratories diagnose human pathogens. Modern automated NAATs require considerably less hands-on time and testing is much simpler than with conventional detection methods. The combination of ease of performance and speed, has made real-time NAATs appealing alterna...

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Disputationen: 2.12.2017

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AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta

Laine, Annina / 27.04.2017

AGGREGAATTORIT ÄÄNITTEIDEN DIGITAALISESSA JAKELUSSA Tekijänoikeuslainsäädännön ja verotuksen näkökulmasta Laine, Annina Tiivistelmä/Referat – Abstract Internet ja digitaalitekniikan kehitys on mullistanut musiikkialaa merkittävästi ja huomattava osa äänitteistä siirtyy nykyään kuuntelijalle digitaalisessa muodossa. Kuluttajille äänitemarkkinoiden digitalisoituminen merkitsee, että mus...

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Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä

Korhonen, Sofie / 27.04.2017

Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Korhonen, Sofie Tiedekunta/Osasto Fakultet/Sektion – Faculty Oikeustieteellinen tiedekunta Laitos/Institution– Department Tekijä/Författare – Author Sofie Korhonen Työn nimi / Arbetets titel – Title Kartellivahingon määrän todistaminen vahingonkorvausoikeudenkäynnissä Oppiaine /Läroämne – Subject Oikeustalo...

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The Patent Economics of Synthetic Biology

Bützow, Alexander / 27.04.2017

The Patent Economics of Synthetic Biology Bützow, Alexander Kyseinen työ tutkii uutta bioteknologian muotoa, synteettistä biologiaa, ja sen suhdetta eurooppalaiseen immateriaalioikeuteen, erityisesti patenttioikeuteen. Tutkielman keskeiset kysymykset koskevat sen selvittämisestä, onko 1) synteettisen biologian keksinnöt systeemisesti soveltumattomia nykyiseen patenttioikeuteen, ja 2...

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Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona

Sotamaa, Rasmus / 27.04.2017

Vastuun rajoittaminen asianajotoimeksiantosopimukseen perustuvan vastuunhallinnan keinona Sotamaa, Rasmus Asianajajan mahdollisuuksiin rajata vastuutaan on perinteisesti suhtauduttu varovaisen torjuvasti niin Suomessa kuin muissakin Pohjoismaissa. Torjuvan suhtautumisen perusteet on usein liitetty asianajotoiminnan erityiseen luonteeseen. Vastuunrajoitukset on nähty erityisesti asianaja...

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